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KMID : 0380420030270010053
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Journal of Prventive Veterinary Medicine
2003 Volume.27 No. 1 p.53 ~ p.58
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Effect of Vitamin A on Hepatic Mitochondrial Activity
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Abstract
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The effect of retinyl palmitate on mitocondrial activity and ATPase of mitochondria obtained from rat liver and their relation were studied. We designed normal, deficient and overdosing groups with supplemented retinyl palmitate amount to normal diets. Normal group diet contained 2.2 mg retinyl palmitate per 1 kg normal diet, deficient group diet contained 0 mg and overdosing group diet contained 6.6 mg. After all rats were fed each diets for 4 months, we examined the reinyl palmitate concentration, mitochondrial activity and ATPase activity in each rat liver mitochondria. Retinyl palmitate concentrations were significantly increased with administerd vitamin A amounts. And the mitochondrial activity studies not showed a significant differences between each group. ATPase activity results showed that normal group activity was higher than deficient group activity. But ATPase activity of overdosing group decreased than deficient group. These results indicate that although it is a high correlation between retinyl palmitate concentration of rat liver and supplemented vitamin A amount, the retinyl palmitate may not act as an inducer to change total mitochondrial activity.
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